Product principles

Based on real-time PCR, Tianlong SMN1 gene detection kit can identify the copy-number variation of the SMN1 at exons 7 and/or 8, by the primers designed for ARMS-PCR and melting curve method, and two copies of the housekeeping gene as the internal reference. The results after being processed by compatible devices and software can identify SMN1 carrier for SMA genetic testing.

Specifications:

• Detection targets: copy number of SMN1 exons 7 and/or 8 in human genomic DNA
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• Limit of detection (LOD): 10 ng/uL
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• Precision variable cofficient of Ct value (CV, %) ?6%
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• Sample type: whole blood
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• No. of tests /kit: 32T/kit
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• Storage Temperature: -15? to -25? for 10 months
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• Compatible Instruments: Tianlong Gentier 96E, Gentier 96R and similar instruments

  Features:
  International standard
  EU CE-Certified, and approved and marketed worldwide.
  Accurate
  High-specificity probes, quantified reactions, for able to identify both heterozygous and homozygous deletions of SMN1 gene.
  Fast and easy
  Compatible with Tianlong automated nucleic acid extraction systems, easy to operate using real-time PCR method; testing and reporting completed in about 2h.
  Economical
  Fast and lower cost compared with other methods such as PCR-RFLP or MLPA.
  Safe
  Automation ready; tube closed throughout the testing procedures; minimized contamination.

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